gallery / domain / zoosporic_holozoa_vs_dikarya / pairwise-diamond / enrichment (novelty)

zoosporic holozoa vs dikarya: functional enrichment (novelty)

One-sided hypergeometric test per term; Benjamini-Hochberg FDR within each scope, level and vocabulary. Candidates are the novelty candidates: gene families present in the IN group and absent from the OUT group. Universe: proteome. Background clustered: True (318843 sequences in 182816 clusters, mmseqs easy-cluster --min-seq-id 0.3 -c 0.8). Family level: one unit per candidate family and per background cluster.

Sources: Pfam: 2026-01-27-Pfam38.2; InterPro entries: 110.0; GO: releases/2026-07-26; analysis generated 2026-10-12T14:56:47. Source tables: studies/eukaryotes/zoosporic_holozoa_vs_dikarya/analysis/enrichment/outputs/proteome_clustered. Full record: PROVENANCE. Run report: report.html.

Caveats

Annotation provenance is not fully recorded: PROVENANCE.yaml lists the per-species annotation files and their checksums, but not the UniProt release they come from.
GO results are secondary. GO annotations include computational evidence (IEA, IBA); the GO evidence column shows if a term has non-IEA support.
Candidate families (pipeline clustering of candidates) and background clusters (mmseqs clustering of the background proteome) are made by different runs, so family-level counts are not fully comparable.
GO covers only 24 of 25 species: Monobrev, Salprose, Capsowcz, Sphaarct, Amphquee, Tricadha, Nemavect, Caeneleg, Drosmela, Homosapi, Batrdend, Batrsala, Spizpunc, Powehirt, Geravari, Syncendo, Syncmicr, Chytconf, Polystew, Rhizglob, Rhizrose, Cateangu, Allomacr, Pirofinn. No GO annotation for Mnemleid; this species adds no units to the GO tests, so those results describe the covered species only.

Summary figure

Annotation coverage

Fraction of proteins with at least one term per vocabulary. Universe = all proteins of the species; candidates = the candidate set.

Species	Set	Proteins	Pfam	Pfam clan	InterPro	GO	Any
Monobrev	universe	9156	73.2%	63.4%	82.1%	68.4%	83.1%
Monobrev	candidates	196	93.4%	65.8%	99.5%	89.3%	99.5%
Salprose	universe	11614	70.3%	59.8%	79.8%	63.8%	80.6%
Salprose	candidates	237	92.0%	64.6%	98.3%	88.6%	98.7%
Capsowcz	universe	8738	79.0%	66.2%	83.8%	71.4%	84.1%
Capsowcz	candidates	125	96.0%	74.4%	100.0%	92.0%	100.0%
Sphaarct	universe	18207	44.2%	36.5%	53.6%	40.7%	54.0%
Sphaarct	candidates	127	86.6%	66.1%	97.6%	83.5%	97.6%
Amphquee	universe	20174	73.0%	63.1%	83.0%	64.0%	83.3%
Amphquee	candidates	383	91.4%	66.8%	99.2%	88.0%	99.5%
Tricadha	universe	11518	84.1%	70.4%	89.9%	77.1%	90.4%
Tricadha	candidates	303	94.1%	69.3%	99.0%	87.1%	99.3%
Nemavect	universe	24428	73.5%	62.6%	80.4%	63.6%	81.0%
Nemavect	candidates	413	94.7%	68.5%	99.5%	84.3%	99.8%
Mnemleid	universe	19289	63.5%	55.6%	72.8%	0.0%	72.8%
Mnemleid	candidates	269	96.3%	66.2%	99.6%	0.0%	99.6%
Caeneleg	universe	19792	71.0%	57.4%	76.1%	58.6%	77.8%
Caeneleg	candidates	148	98.0%	79.0%	100.0%	96.0%	100.0%
Drosmela	universe	13814	80.4%	63.1%	84.4%	74.7%	87.0%
Drosmela	candidates	210	97.1%	71.0%	100.0%	90.5%	100.0%
Homosapi	universe	20652	94.4%	75.1%	96.4%	93.8%	97.4%
Homosapi	candidates	373	97.0%	70.8%	99.5%	98.9%	100.0%
Batrdend	universe	8610	68.0%	55.5%	75.5%	64.4%	75.9%
Batrdend	candidates	258	91.9%	66.7%	98.8%	83.0%	98.8%
Batrsala	universe	11060	60.0%	49.6%	66.2%	53.6%	66.6%
Batrsala	candidates	281	94.0%	64.8%	99.6%	83.3%	99.6%
Spizpunc	universe	8940	77.0%	62.6%	81.7%	68.6%	82.1%
Spizpunc	candidates	302	97.0%	66.2%	99.3%	81.8%	99.7%
Powehirt	universe	6533	88.3%	72.6%	92.2%	79.7%	92.5%
Powehirt	candidates	265	94.3%	64.5%	99.6%	81.5%	99.6%
Geravari	universe	8696	72.9%	59.8%	78.6%	65.8%	79.0%
Geravari	candidates	272	93.8%	65.1%	98.9%	80.5%	99.3%
Syncendo	universe	7895	64.4%	52.3%	69.6%	59.2%	70.0%
Syncendo	candidates	205	93.7%	62.0%	99.5%	82.0%	99.5%
Syncmicr	universe	6304	90.2%	75.6%	94.1%	82.1%	94.3%
Syncmicr	candidates	237	94.1%	63.7%	99.6%	81.0%	99.6%
Chytconf	universe	10661	80.1%	68.1%	86.9%	72.9%	87.3%
Chytconf	candidates	287	93.4%	65.2%	99.7%	81.2%	99.7%
Polystew	universe	9229	72.1%	60.4%	80.4%	63.9%	80.9%
Polystew	candidates	270	95.2%	65.2%	99.6%	84.1%	99.6%
Rhizglob	universe	16725	56.7%	48.2%	65.1%	50.4%	65.5%
Rhizglob	candidates	292	91.8%	66.1%	99.0%	81.5%	99.3%
Rhizrose	universe	11454	62.5%	51.2%	70.1%	55.4%	70.5%
Rhizrose	candidates	290	92.8%	61.0%	97.6%	80.7%	98.6%
Cateangu	universe	12590	48.7%	39.4%	55.5%	44.3%	55.8%
Cateangu	candidates	240	91.2%	62.5%	99.2%	85.0%	100.0%
Allomacr	universe	18611	65.4%	53.1%	72.9%	59.8%	73.3%
Allomacr	candidates	389	91.5%	64.8%	99.5%	86.9%	99.5%
Pirofinn	universe	10768	67.0%	56.0%	73.5%	57.1%	73.9%
Pirofinn	candidates	243	93.8%	63.0%	98.8%	81.9%	99.2%
ALL_IN	universe	325458	70.3%	58.4%	77.0%	60.1%	77.7%
ALL_IN	candidates	6615	93.8%	66.3%	99.2%	81.9%	99.5%

Tests summary

Per vocabulary: terms with FDR < 0.05 / terms tested. Protein level counts proteins; family level counts candidate families and background clusters.

Scope	Level	Cand. units	Pfam sig / tested	Pfam clan sig / tested	InterPro sig / tested	GO sig / tested
whole_set	family	2958	297 / 6027	48 / 600	564 / 12289	532 / 13705
whole_set	protein	6615	388 / 7694	72 / 619	709 / 16074	691 / 15077
Allomacr	family	265	7 / 440	8 / 251	17 / 1093	83 / 2399
Allomacr	protein	389	17 / 787	13 / 311	40 / 1845	132 / 3038
Amphquee	family	346	6 / 661	11 / 296	35 / 1516	134 / 2802
Amphquee	protein	383	12 / 804	13 / 325	47 / 1828	157 / 2991
Batrdend	family	254	1 / 248	4 / 200	6 / 650	67 / 1987
Batrdend	protein	258	2 / 307	8 / 215	11 / 785	74 / 2076
Batrsala	family	270	2 / 272	6 / 210	8 / 692	70 / 1949
Batrsala	protein	281	5 / 330	7 / 223	17 / 819	96 / 2038
Caeneleg	family	134	1 / 513	1 / 276	3 / 1240	62 / 3878
Caeneleg	protein	148	5 / 700	9 / 299	15 / 1651	91 / 4192
Capsowcz	family	119	2 / 364	2 / 242	5 / 890	15 / 2062
Capsowcz	protein	125	3 / 421	3 / 253	7 / 1020	21 / 2145
Cateangu	family	227	2 / 272	2 / 202	5 / 692	89 / 1944
Cateangu	protein	240	4 / 352	5 / 219	13 / 880	94 / 2050
Chytconf	family	256	2 / 396	3 / 244	9 / 974	84 / 2140
Chytconf	protein	287	6 / 590	7 / 280	12 / 1389	92 / 2408
Drosmela	family	197	8 / 529	5 / 278	16 / 1233	115 / 5154
Drosmela	protein	210	10 / 711	6 / 308	21 / 1635	131 / 5424
Geravari	family	270	3 / 317	8 / 228	9 / 800	105 / 2048
Geravari	protein	272	3 / 372	8 / 241	11 / 928	106 / 2142
Homosapi	family	321	12 / 758	11 / 334	25 / 1702	142 / 10060
Homosapi	protein	373	20 / 1326	18 / 394	55 / 2898	261 / 10899
Mnemleid	family	259	2 / 522	7 / 266	8 / 1197	0 / 0 (skipped_no_annotated_candidates)
Mnemleid	protein	269	4 / 643	11 / 288	13 / 1467	0 / 0 (skipped_no_annotated_candidates)
Monobrev	family	193	2 / 382	6 / 221	4 / 892	66 / 2094
Monobrev	protein	196	3 / 419	8 / 228	7 / 992	67 / 2169
Nemavect	family	374	5 / 745	6 / 341	21 / 1798	121 / 3040
Nemavect	protein	413	14 / 914	8 / 370	41 / 2214	147 / 3294
Pirofinn	family	233	1 / 318	4 / 208	9 / 788	62 / 2191
Pirofinn	protein	243	1 / 404	8 / 224	9 / 1002	86 / 2360
Polystew	family	260	3 / 323	6 / 217	8 / 810	75 / 1986
Polystew	protein	270	6 / 406	9 / 235	16 / 982	95 / 2095
Powehirt	family	262	3 / 308	8 / 219	6 / 761	88 / 1993
Powehirt	protein	265	3 / 358	9 / 234	6 / 880	87 / 2078
Rhizglob	family	273	1 / 444	6 / 244	15 / 1061	82 / 2437
Rhizglob	protein	292	3 / 596	8 / 268	14 / 1369	94 / 2624
Rhizrose	family	289	6 / 369	7 / 232	6 / 915	107 / 2125
Rhizrose	protein	290	6 / 408	7 / 244	9 / 1016	116 / 2194
Salprose	family	225	3 / 476	7 / 252	5 / 1094	83 / 2211
Salprose	protein	237	5 / 523	5 / 259	10 / 1218	84 / 2289
Sphaarct	family	125	1 / 391	2 / 237	4 / 1014	32 / 2246
Sphaarct	protein	127	1 / 440	2 / 246	4 / 1114	32 / 2303
Spizpunc	family	301	4 / 365	8 / 232	12 / 889	86 / 2446
Spizpunc	protein	302	4 / 424	8 / 245	12 / 1021	88 / 2536
Syncendo	family	203	1 / 259	5 / 198	0 / 649	62 / 1870
Syncendo	protein	205	2 / 296	7 / 214	3 / 735	63 / 1923
Syncmicr	family	236	1 / 298	7 / 212	3 / 750	68 / 1942
Syncmicr	protein	237	1 / 364	8 / 224	6 / 890	78 / 2049
Tricadha	family	263	5 / 442	6 / 273	8 / 1067	106 / 2509
Tricadha	protein	303	10 / 574	7 / 289	19 / 1393	123 / 2728

Top 25 Pfam terms (whole set, family level)

25 rows shown, ordered by FDR then p-value; 25 have FDR < 0.05 (bold).

Term	Name	k / N cand.	n / M bg	Fold	FDR (BH)
PF00211	Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain	94 / 2711	171 / 107786	21.856	6.67e-99
PF17958	EF-hand_13: EF-hand domain	23 / 2711	24 / 107786	38.102	1.05e-32
PF18027	Pepdidase_M14_N: Cytosolic carboxypeptidase N-terminal domain	25 / 2711	32 / 107786	31.062	5.29e-31
PF03133	TTL: Tubulin-tyrosine ligase family	37 / 2711	108 / 107786	13.621	1.56e-28
PF07701	HNOBA: Heme NO binding associated	20 / 2711	27 / 107786	29.451	8.67e-24
PF03493	BK_channel_a: Calcium-activated BK potassium channel alpha subunit	20 / 2711	28 / 107786	28.399	2.47e-23
PF00246	Peptidase_M14: Zinc carboxypeptidase	30 / 2711	86 / 107786	13.869	2.51e-23
PF06294	CH_2: CH-like domain in sperm protein	21 / 2711	36 / 107786	23.193	6.99e-22
PF00027	cNMP_binding: Cyclic nucleotide-binding domain	48 / 2711	303 / 107786	6.298	2.94e-21
PF22614	Slo-like_RCK: Calcium-activated potassium channel slowpoke-like RCK domain	20 / 2711	34 / 107786	23.388	5.74e-21
PF20811	PARG_cat_N: Poly (ADP-ribose) glycohydrolase (PARG), helical domain	15 / 2711	16 / 107786	37.274	8.41e-21
PF07700	HNOB: Haem-NO-binding	14 / 2711	14 / 107786	39.759	1.97e-20
PF05028	PARG_cat_C: Poly (ADP-ribose) glycohydrolase (PARG), Macro domain fold	17 / 2711	25 / 107786	27.036	2.54e-19
PF00003	7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR	51 / 2711	385 / 107786	5.267	2.95e-19
PF30846	CEP164_N: CEP164 N-terminal domain	15 / 2711	18 / 107786	33.132	3.00e-19
PF28678	CXorf58_MFI: CXorf58/MFI domain	16 / 2711	23 / 107786	27.658	1.92e-18
PF25462	Beta-barrel_INTS6: INTS6 beta-barrel domain	13 / 2711	14 / 107786	36.919	7.60e-18
PF26187	Ig_NPHP4_4th: NPH4 Ig-like domain 4	13 / 2711	15 / 107786	34.458	5.26e-17
PF02996	Prefoldin: Prefoldin subunit	18 / 2711	38 / 107786	18.833	1.01e-16
PF13870	CCDC113_CCDC96_CC: CCDC113/CCDC96, coiled-coil	14 / 2711	19 / 107786	29.296	1.16e-16
PF21773	ODAD1_CC: ODAD1 central coiled coil region	14 / 2711	19 / 107786	29.296	1.16e-16
PF23277	Ig_Dlec1_1: Deleted in lung and esophageal cancer protein 1 Ig domain	12 / 2711	13 / 107786	36.7	2.18e-16
PF01167	Tub: Tub family	14 / 2711	20 / 107786	27.831	3.29e-16
PF08683	CAMSAP_CKK: Microtubule-binding calmodulin-regulated spectrin-associated	14 / 2711	20 / 107786	27.831	3.29e-16
PF03607	DCX: Doublecortin	19 / 2711	47 / 107786	16.073	3.29e-16

Top 25 InterPro terms (whole set, family level)

25 rows shown, ordered by FDR then p-value; 25 have FDR < 0.05 (bold).

Term	Name	k / N cand.	n / M bg	Fold	FDR (BH)
IPR001054	Domain:Adenylyl cyclase class-3/4/guanylyl cyclase	99 / 2923	190 / 123867	22.08	1.88e-103
IPR029787	Homologous_superfamily:Nucleotide cyclase	99 / 2923	214 / 123867	19.604	5.59e-97
IPR018297	Conserved_site:Adenylyl cyclase class-4/guanylyl cyclase, conserved site	36 / 2923	53 / 123867	28.784	1.92e-42
IPR050821	Family:Cytosolic carboxypeptidase	30 / 2923	40 / 123867	31.783	2.75e-37
IPR041534	Domain:PP2A regulatory subunit B'', EF-hand domain	23 / 2923	24 / 123867	40.611	2.00e-33
IPR040626	Domain:Cytosolic carboxypeptidase, N-terminal	25 / 2923	32 / 123867	33.107	1.12e-31
IPR011989	Homologous_superfamily:Armadillo-like helical	142 / 2923	1839 / 123867	3.272	4.97e-31
IPR004344	Family:Tubulin-tyrosine ligase/Tubulin polyglutamylase	37 / 2923	108 / 123867	14.518	1.71e-29
IPR026983	Family:Dynein heavy chain	41 / 2923	172 / 123867	10.101	7.47e-26
IPR000834	Domain:Peptidase M14, carboxypeptidase A	31 / 2923	87 / 123867	15.1	3.82e-25
IPR011645	Domain:Haem NO binding associated	20 / 2923	27 / 123867	31.39	2.28e-24
IPR003929	Domain:Calcium-activated potassium channel BK, alpha subunit	20 / 2923	28 / 123867	30.269	7.15e-24
IPR011992	Homologous_superfamily:EF-hand domain pair	95 / 2923	1108 / 123867	3.633	1.18e-23
IPR036322	Homologous_superfamily:WD40-repeat-containing domain superfamily	144 / 2923	2277 / 123867	2.68	6.02e-23
IPR015943	Homologous_superfamily:WD40/YVTN repeat-like-containing domain superfamily	155 / 2923	2583 / 123867	2.543	1.55e-22
IPR010441	Domain:CH-like domain in sperm protein	21 / 2923	36 / 123867	24.72	1.92e-22
IPR042463	Homologous_superfamily:Haem NO binding associated domain superfamily	15 / 2923	15 / 123867	42.377	2.73e-22
IPR018490	Homologous_superfamily:Cyclic nucleotide-binding domain superfamily	53 / 2923	382 / 123867	5.879	4.81e-22
IPR016024	Homologous_superfamily:Armadillo-type fold	156 / 2923	2649 / 123867	2.496	5.67e-22
IPR039720	Family:Transmembrane protein 94	17 / 2923	21 / 123867	34.305	7.01e-22
IPR001680	Repeat:WD40 repeat	129 / 2923	1975 / 123867	2.768	8.97e-22
IPR003148	Domain:Regulator of K+ conductance, N-terminal lobe	20 / 2923	34 / 123867	24.927	1.53e-21
IPR000595	Domain:Cyclic nucleotide-binding domain	51 / 2923	363 / 123867	5.954	1.60e-21
IPR007724	Family:Poly(ADP-ribose) glycohydrolase	17 / 2923	22 / 123867	32.746	2.51e-21
IPR048362	Domain:Poly (ADP-ribose) glycohydrolase, helical domain	15 / 2923	16 / 123867	39.728	2.91e-21

Top 15 GO terms (whole set, family level) — secondary, computational evidence (IEA/IBA) included

15 rows shown, ordered by FDR then p-value; 15 have FDR < 0.05 (bold).

Term	Name	k / N cand.	n / M bg	Fold	FDR (BH)	GO evidence	Families with non-IEA
GO:0005929	cellular_component:cilium	287 / 2373	1192 / 91079	9.241	7.63e-184	has_non_IEA	125
GO:0007017	biological_process:microtubule-based process	386 / 2373	2863 / 91079	5.175	1.83e-156	has_non_IEA	183
GO:0007018	biological_process:microtubule-based movement	271 / 2373	1408 / 91079	7.387	8.10e-147	has_non_IEA	127
GO:0005930	cellular_component:axoneme	158 / 2373	443 / 91079	13.689	7.56e-129	has_non_IEA	74
GO:0044782	biological_process:cilium organization	210 / 2373	916 / 91079	8.799	1.07e-128	has_non_IEA	115
GO:0120025	cellular_component:plasma membrane bounded cell projection	339 / 2373	2765 / 91079	4.706	4.23e-124	has_non_IEA	157
GO:0042995	cellular_component:cell projection	339 / 2373	2772 / 91079	4.694	7.69e-124	has_non_IEA	157
GO:0060271	biological_process:cilium assembly	191 / 2373	805 / 91079	9.107	8.82e-120	has_non_IEA	105
GO:0120031	biological_process:plasma membrane bounded cell projection assembly	199 / 2373	895 / 91079	8.534	3.00e-119	has_non_IEA	112
GO:0030031	biological_process:cell projection assembly	200 / 2373	909 / 91079	8.445	5.52e-119	has_non_IEA	113
GO:0036064	cellular_component:ciliary basal body	151 / 2373	610 / 91079	9.501	5.57e-97	has_non_IEA	72
GO:0120036	biological_process:plasma membrane bounded cell projection organization	228 / 2373	1672 / 91079	5.234	5.68e-91	has_non_IEA	130
GO:0005815	cellular_component:microtubule organizing center	223 / 2373	1724 / 91079	4.965	2.32e-84	has_non_IEA	113
GO:0042073	biological_process:intraciliary transport	93 / 2373	226 / 91079	15.794	4.60e-82	has_non_IEA	38
GO:0030030	biological_process:cell projection organization	230 / 2373	1909 / 91079	4.624	5.23e-81	has_non_IEA	132

Actin cytoskeleton controls

Known actin-related families and how many of their proteins pass each filter. Protein ID columns are left out.

control	pfam_ids	desc_regex	IN_universe	IN_in_matrix	IN_pass_ingroup_rule	candidates	near_miss_out1	near_miss_out2	n_Monobrev	n_Salprose	n_Capsowcz	n_Sphaarct	n_Amphquee	n_Tricadha	n_Nemavect	n_Mnemleid	n_Caeneleg	n_Drosmela	n_Homosapi	n_Batrdend	n_Batrsala	n_Spizpunc	n_Powehirt	n_Geravari	n_Syncendo	n_Syncmicr	n_Chytconf	n_Polystew	n_Rhizglob	n_Rhizrose	n_Cateangu	n_Allomacr	n_Pirofinn	n_Sacccere	n_Schipomb	n_Neurcras	n_Aspenidu	n_Mycomayd	n_Crypneof	n_Coprcine
Arp2/3 ARPC2 (P34-Arc)	PF04045		26	26	26	0	0	0	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	2	1	1	1	1	1	1	1	1
Arp2/3 ARPC3 (P21-Arc)	PF04062		27	27	27	0	0	0	1	1	1	1	1	1	1	1	1	2	1	1	1	1	1	1	1	1	1	1	1	1	1	2	1	1	1	1	1	1	1	1
Arp2/3 ARPC4	PF05856		25	25	25	0	0	0	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
Arp2/3 ARPC5 (P16-Arc)	PF04699		28	28	24	0	0	1	0	1	1	1	1	1	1	1	2	1	2	1	1	1	1	1	1	1	2	1	1	1	1	2	1	1	1	1	1	1	1	1
Arp2/3 ARPC1 (description only)		arp2/3 complex.*(41\|p41\|subunit 1)\|ARPC1	3	3	3	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0
Arp2 / Arp3 (description only)		actin-related protein (2\|3)\b\|\bARP[23]\b	169	169	162	0	0	1	5	6	5	5	6	6	7	6	8	8	11	6	7	6	7	6	7	6	6	8	5	6	7	13	6	7	7	6	7	7	5	5
WAVE complex NCKAP1	PF09735		25	25	24	22	0	0	1	1	1	0	1	2	1	1	1	1	2	1	1	1	1	1	1	1	0	1	0	1	1	2	1	0	0	0	0	0	0	0
WAVE complex CYFIP (FragX_IP)	PF05994		31	30	27	26	0	0	1	2	1	0	5	1	1	1	1	1	2	1	1	1	1	1	1	1	0	1	0	1	1	4	1	0	0	0	0	0	0	0
WAVE complex ABI	PF07815\|PF27594		13	12	7	0	0	0	0	1	1	0	1	1	3	1	1	1	3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
SCAR/WAVE (SCAR_helical)	PF27569		27	27	15	15	0	0	1	2	1	0	2	1	1	3	1	1	3	1	1	1	1	1	1	1	0	1	0	1	1	0	1	0	0	0	0	0	0	0
WASP family (WH1)	PF00568		63	61	19	0	0	2	2	3	3	3	5	5	5	3	2	4	11	1	1	1	1	1	1	1	1	1	1	1	1	4	1	1	1	1	1	1	1	2
WH2 motif (WASP, WAVE, others)	PF02205		70	58	15	5	0	1	3	6	5	2	4	3	3	4	4	4	15	3	1	1	1	1	1	1	1	1	0	1	1	2	2	2	2	1	3	2	2	2
Formin FH2	PF02181		162	158	130	7	9	14	8	8	6	8	12	4	11	8	7	6	15	4	6	4	4	4	3	4	5	6	5	5	3	9	7	2	3	1	1	2	1	2
Formin Drf_GBD / Drf_FH3 / Drf_DAD	PF06371\|PF06367\|PF06345		115	114	88	5	5	6	5	5	3	5	7	4	9	3	3	5	9	3	4	4	3	4	2	3	3	4	3	7	3	7	7	1	4	2	2	2	2	3
Ena/VASP (VASP_tetra)	PF08776		5	5	0	0	0	0	1	0	0	0	0	0	0	0	0	1	3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Coronin (description only)		coronin	63	63	61	2	0	0	1	1	2	2	2	2	4	2	2	2	7	1	1	3	3	4	1	2	4	2	2	4	1	4	4	1	1	1	1	1	1	1
Cortactin (HS1_rep)	PF02218		11	11	10	1	0	0	1	1	1	0	1	1	1	1	0	1	2	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
Myosin 2 tail (Myosin_tail_1)	PF01576		63	61	52	0	0	0	1	1	3	1	3	0	2	6	8	4	19	1	1	1	1	1	1	1	1	1	1	2	0	1	2	0	0	0	0	0	0	1
Myosin head (all myosins)	PF00063		377	377	371	0	0	0	32	32	23	15	19	12	20	10	17	14	39	7	8	9	9	7	6	9	13	7	14	12	8	21	14	5	5	4	5	4	4	5

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