serinales vs pichiales: functional enrichment (loss)
One-sided hypergeometric test per term; Benjamini-Hochberg FDR within each scope, level and vocabulary. Candidates are the loss candidates: gene families present in the OUT group and absent from the IN group. Universe: proteome. Background clustered: True (80405 sequences in 21748 clusters, mmseqs easy-cluster --min-seq-id 0.3 -c 0.8). Family level: one unit per candidate family and per background cluster.
Sources: Pfam: 2026-01-27-Pfam38.2; InterPro entries: 110.0; GO: releases/2026-07-26; analysis generated 2026-10-12T18:19:41. Source tables: studies/fungi/serinales_vs_pichiales/analysis/enrichment/outputs/loss/proteome_clustered.
Full record: PROVENANCE. Run report: report.html.
Caveats
- Annotation provenance is not fully recorded: PROVENANCE.yaml lists the per-species annotation files and their checksums, but not the UniProt release they come from.
- GO results are secondary. GO annotations include computational evidence (IEA, IBA); the GO evidence column shows if a term has non-IEA support.
- Candidate families (pipeline clustering of candidates) and background clusters (mmseqs clustering of the background proteome) are made by different runs, so family-level counts are not fully comparable.
Summary figure
Annotation coverage
Fraction of proteins with at least one term per vocabulary. Universe = all proteins of the species; candidates = the candidate set.
| Species | Set | Proteins | Pfam | Pfam clan | InterPro | GO | Any |
|---|---|---|---|---|---|---|---|
| Komaphaf | universe | 5075 | 87.7% | 68.1% | 90.6% | 82.5% | 90.9% |
| Komaphaf | candidates | 12 | 83.3% | 66.7% | 83.3% | 50.0% | 83.3% |
| Ogatpara | universe | 5319 | 88.8% | 71.1% | 91.9% | 84.1% | 92.2% |
| Ogatpara | candidates | 14 | 85.7% | 71.4% | 92.9% | 50.0% | 92.9% |
| Kuracaps | universe | 6027 | 84.6% | 67.4% | 88.0% | 79.2% | 88.3% |
| Kuracaps | candidates | 12 | 83.3% | 58.3% | 91.7% | 66.7% | 91.7% |
| Pichmemb | universe | 5536 | 81.6% | 64.9% | 85.0% | 77.1% | 85.3% |
| Pichmemb | candidates | 12 | 75.0% | 50.0% | 91.7% | 33.3% | 91.7% |
| Pichkudr | universe | 5146 | 86.7% | 68.2% | 90.4% | 81.9% | 90.7% |
| Pichkudr | candidates | 9 | 88.9% | 55.6% | 88.9% | 44.4% | 88.9% |
| Bretnaar | universe | 5164 | 88.4% | 70.2% | 91.7% | 82.9% | 92.2% |
| Bretnaar | candidates | 12 | 100.0% | 83.3% | 91.7% | 50.0% | 100.0% |
| Eeninana | universe | 4703 | 88.3% | 70.9% | 91.8% | 83.4% | 92.0% |
| Eeninana | candidates | 11 | 81.8% | 63.6% | 90.9% | 27.3% | 90.9% |
| Ogatpoly | universe | 6801 | 68.1% | 55.0% | 70.8% | 64.0% | 71.0% |
| Ogatpoly | candidates | 11 | 90.9% | 72.7% | 100.0% | 45.5% | 100.0% |
| Pachtann | universe | 5643 | 85.8% | 67.1% | 88.9% | 80.3% | 89.3% |
| Pachtann | candidates | 11 | 100.0% | 72.7% | 100.0% | 63.6% | 100.0% |
| Sacccere | universe | 6066 | 88.6% | 66.3% | 90.9% | 94.8% | 96.4% |
| Sacccere | candidates | 12 | 91.7% | 75.0% | 91.7% | 100.0% | 100.0% |
| Kluylact | universe | 5071 | 90.6% | 68.8% | 93.2% | 84.4% | 93.8% |
| Kluylact | candidates | 14 | 85.7% | 42.9% | 92.9% | 50.0% | 92.9% |
| Lachther | universe | 5093 | 91.7% | 69.8% | 94.6% | 85.0% | 95.0% |
| Lachther | candidates | 12 | 91.7% | 50.0% | 100.0% | 75.0% | 100.0% |
| Candglab | universe | 5198 | 91.2% | 68.9% | 94.1% | 89.9% | 95.3% |
| Candglab | candidates | 10 | 100.0% | 90.0% | 100.0% | 90.0% | 100.0% |
| Torudelb | universe | 4974 | 92.9% | 70.1% | 95.3% | 90.9% | 96.5% |
| Torudelb | candidates | 8 | 87.5% | 75.0% | 87.5% | 100.0% | 100.0% |
| Eremgoss | universe | 4758 | 91.1% | 68.8% | 94.3% | 86.5% | 94.8% |
| Eremgoss | candidates | 9 | 88.9% | 55.6% | 88.9% | 44.4% | 88.9% |
| ALL_OUT | universe | 80574 | 86.6% | 67.4% | 89.6% | 82.8% | 90.5% |
| ALL_OUT | candidates | 169 | 88.8% | 65.1% | 92.9% | 58.6% | 94.7% |
Tests summary
Per vocabulary: terms with FDR < 0.05 / terms tested. Protein level counts proteins; family level counts candidate families and background clusters.
| Scope | Level | Cand. units | Pfam sig / tested | Pfam clan sig / tested | InterPro sig / tested | GO sig / tested |
|---|---|---|---|---|---|---|
| whole_set | family | 74 | 8 / 1248 | 4 / 318 | 13 / 2367 | 30 / 4490 |
| whole_set | protein | 169 | 20 / 4360 | 8 / 478 | 35 / 8918 | 106 / 7224 |
| Bretnaar | family | 12 | 0 / 152 | 0 / 173 | 0 / 446 | 0 / 1865 |
| Bretnaar | protein | 12 | 0 / 199 | 0 / 188 | 0 / 559 | 0 / 2003 |
| Candglab | family | 10 | 0 / 153 | 0 / 169 | 0 / 452 | 0 / 3055 |
| Candglab | protein | 10 | 0 / 215 | 0 / 189 | 0 / 597 | 0 / 3216 |
| Eeninana | family | 11 | 0 / 137 | 0 / 164 | 0 / 412 | 0 / 1812 |
| Eeninana | protein | 11 | 0 / 178 | 0 / 181 | 0 / 516 | 0 / 1925 |
| Eremgoss | family | 8 | 0 / 137 | 0 / 169 | 0 / 417 | 0 / 2006 |
| Eremgoss | protein | 9 | 1 / 165 | 1 / 180 | 3 / 493 | 0 / 2089 |
| Kluylact | family | 14 | 0 / 150 | 0 / 171 | 0 / 450 | 0 / 1948 |
| Kluylact | protein | 14 | 0 / 187 | 0 / 184 | 0 / 536 | 0 / 2051 |
| Komaphaf | family | 12 | 0 / 145 | 0 / 172 | 0 / 442 | 0 / 2424 |
| Komaphaf | protein | 12 | 0 / 181 | 0 / 186 | 0 / 530 | 0 / 2522 |
| Kuracaps | family | 12 | 0 / 174 | 0 / 184 | 0 / 488 | 0 / 2472 |
| Kuracaps | protein | 12 | 0 / 237 | 0 / 201 | 0 / 622 | 0 / 2583 |
| Lachther | family | 12 | 0 / 150 | 0 / 175 | 0 / 448 | 0 / 1936 |
| Lachther | protein | 12 | 0 / 193 | 0 / 185 | 0 / 544 | 0 / 2056 |
| Ogatpara | family | 14 | 0 / 157 | 0 / 180 | 0 / 468 | 0 / 2456 |
| Ogatpara | protein | 14 | 0 / 203 | 0 / 192 | 0 / 582 | 0 / 2574 |
| Ogatpoly | family | 11 | 0 / 168 | 0 / 182 | 0 / 481 | 0 / 2038 |
| Ogatpoly | protein | 11 | 0 / 207 | 0 / 194 | 0 / 585 | 0 / 2155 |
| Pachtann | family | 11 | 0 / 171 | 0 / 176 | 0 / 474 | 0 / 2082 |
| Pachtann | protein | 11 | 0 / 227 | 0 / 190 | 0 / 606 | 0 / 2230 |
| Pichkudr | family | 9 | 0 / 150 | 0 / 174 | 0 / 424 | 0 / 2014 |
| Pichkudr | protein | 9 | 0 / 202 | 0 / 191 | 0 / 543 | 0 / 2138 |
| Pichmemb | family | 12 | 0 / 153 | 0 / 176 | 0 / 450 | 0 / 2318 |
| Pichmemb | protein | 12 | 0 / 200 | 0 / 194 | 0 / 565 | 0 / 2420 |
| Sacccere | family | 12 | 0 / 167 | 0 / 173 | 0 / 483 | 0 / 3436 |
| Sacccere | protein | 12 | 0 / 269 | 0 / 200 | 0 / 711 | 0 / 3712 |
| Torudelb | family | 8 | 0 / 146 | 0 / 173 | 0 / 438 | 0 / 3143 |
| Torudelb | protein | 8 | 0 / 195 | 0 / 188 | 0 / 544 | 0 / 3235 |
Top 25 Pfam terms (whole set, family level)
25 rows shown, ordered by FDR then p-value; 8 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) |
|---|---|---|---|---|---|
| PF29832 | SOV1_middle: SOV1 mitochondrial middle domain | 6 / 61 | 7 / 14277 | 200.614 | 4.11e-11 |
| PF01417 | ENTH: ENTH domain | 7 / 61 | 17 / 14277 | 96.373 | 1.23e-10 |
| PF00011 | HSP20: Hsp20/alpha crystallin family | 6 / 61 | 9 / 14277 | 156.033 | 1.23e-10 |
| PF10307 | HAD_SAK_1: HAD domain family 1 in Swiss Army Knife RNA repair proteins | 6 / 61 | 9 / 14277 | 156.033 | 1.23e-10 |
| PF02037 | SAP: SAP domain | 5 / 61 | 24 / 14277 | 48.76 | 1.20e-05 |
| PF08528 | Whi5: Whi5 like | 3 / 61 | 15 / 14277 | 46.81 | 0.007 |
| PF07724 | AAA_2: AAA domain (Cdc48 subfamily) | 2 / 61 | 5 / 14277 | 93.62 | 0.028 |
| PF12330 | Haspin_kinase: Haspin like kinase domain | 2 / 61 | 5 / 14277 | 93.62 | 0.028 |
| PF30880 | PRTT-like_M: Transcriptional activator of proteases prtT middle domain | 2 / 61 | 12 / 14277 | 39.008 | 0.160 |
| PF02936 | COX4: Cytochrome c oxidase subunit IV | 2 / 61 | 13 / 14277 | 36.008 | 0.170 |
| PF09783 | Vac_ImportDeg: Vacuolar import and degradation protein | 1 / 61 | 5 / 14277 | 46.81 | 1.000 |
| PF28268 | Ig-like_NNF2: NNF2 Ig-like domain | 1 / 61 | 6 / 14277 | 39.008 | 1.000 |
| PF28337 | NNF2_middle: NNF2 middle helical domain | 1 / 61 | 6 / 14277 | 39.008 | 1.000 |
| PF08693 | SKG6: SKG6 family | 1 / 61 | 7 / 14277 | 33.436 | 1.000 |
| PF29078 | SFG1_C: SFG1 C-terminal domain | 1 / 61 | 11 / 14277 | 21.277 | 1.000 |
| PF13812 | PPR_3: Pentatricopeptide repeat domain | 1 / 61 | 12 / 14277 | 19.504 | 1.000 |
| PF01398 | JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease | 1 / 61 | 13 / 14277 | 18.004 | 1.000 |
| PF29452 | FAR1_N: FAR1 N-terminal domain | 1 / 61 | 16 / 14277 | 14.628 | 1.000 |
| PF00172 | Zn_clus: Fungal Zn(2)-Cys(6) binuclear cluster domain | 4 / 61 | 387 / 14277 | 2.419 | 1.000 |
| PF08550 | GATA_AreA: Nitrogen regulatory protein areA, GATA-like domain | 1 / 61 | 25 / 14277 | 9.362 | 1.000 |
| PF04193 | PQ-loop: PQ loop repeat | 1 / 61 | 29 / 14277 | 8.071 | 1.000 |
| PF00004 | AAA: ATPase family associated with various cellular activities (AAA) | 0 / 61 | 50 / 14277 | 0.0 | 1.000 |
| PF00005 | ABC_tran: ABC transporter | 0 / 61 | 30 / 14277 | 0.0 | 1.000 |
| PF00009 | GTP_EFTU: Elongation factor Tu GTP binding domain | 0 / 61 | 21 / 14277 | 0.0 | 1.000 |
| PF00010 | HLH: Helix-loop-helix DNA-binding domain | 0 / 61 | 64 / 14277 | 0.0 | 1.000 |
Top 25 InterPro terms (whole set, family level)
25 rows shown, ordered by FDR then p-value; 13 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) |
|---|---|---|---|---|---|
| IPR063435 | Domain:SOV1, middle domain | 6 / 66 | 7 / 15133 | 196.532 | 9.00e-11 |
| IPR002068 | Domain:Alpha crystallin/Hsp20 domain | 6 / 66 | 9 / 15133 | 152.859 | 2.68e-10 |
| IPR018812 | Domain:Swiss Army Knife RNA repair protein, HAD domain | 6 / 66 | 9 / 15133 | 152.859 | 2.68e-10 |
| IPR031107 | Family:Small heat shock protein | 6 / 66 | 9 / 15133 | 152.859 | 2.68e-10 |
| IPR013809 | Domain:ENTH domain | 7 / 66 | 25 / 15133 | 64.201 | 4.63e-09 |
| IPR008978 | Homologous_superfamily:HSP20-like chaperone | 6 / 66 | 14 / 15133 | 98.266 | 6.29e-09 |
| IPR008942 | Homologous_superfamily:ENTH/VHS | 7 / 66 | 42 / 15133 | 38.215 | 1.75e-07 |
| IPR003034 | Domain:SAP domain | 5 / 66 | 25 / 15133 | 45.858 | 1.99e-05 |
| IPR036361 | Homologous_superfamily:SAP domain superfamily | 5 / 66 | 32 / 15133 | 35.826 | 6.54e-05 |
| IPR039198 | Family:Srl3/Whi5 | 3 / 66 | 7 / 15133 | 98.266 | 6.48e-04 |
| IPR013734 | Conserved_site:Transcription factor Nrm1/Whi5 | 3 / 66 | 15 / 15133 | 45.858 | 0.007 |
| IPR019489 | Domain:Clp ATPase, C-terminal | 2 / 66 | 5 / 15133 | 91.715 | 0.034 |
| IPR024604 | Domain:Serine/threonine-protein kinase haspin, C-terminal | 2 / 66 | 5 / 15133 | 91.715 | 0.034 |
| IPR011990 | Homologous_superfamily:Tetratricopeptide-like helical domain superfamily | 6 / 66 | 250 / 15133 | 5.503 | 0.128 |
| IPR004203 | Family:Cytochrome c oxidase subunit IV family | 2 / 66 | 13 / 15133 | 35.275 | 0.224 |
| IPR036639 | Homologous_superfamily:Cytochrome c oxidase subunit IV superfamily | 2 / 66 | 15 / 15133 | 30.572 | 0.281 |
| IPR015915 | Homologous_superfamily:Kelch-type beta-propeller | 2 / 66 | 23 / 15133 | 19.938 | 0.622 |
| IPR018618 | Family:GID complex substrate-recognition subunit 4/10-like | 1 / 66 | 5 / 15133 | 45.858 | 1.000 |
| IPR003959 | Domain:ATPase, AAA-type, core | 2 / 66 | 53 / 15133 | 8.652 | 1.000 |
| IPR050667 | Family:Pentatricopeptide repeat-containing protein | 1 / 66 | 6 / 15133 | 38.215 | 1.000 |
| IPR060142 | Domain:NNF2, Ig-like domain | 1 / 66 | 6 / 15133 | 38.215 | 1.000 |
| IPR060657 | Domain:NNF2-like, helical region | 1 / 66 | 6 / 15133 | 38.215 | 1.000 |
| IPR014805 | Family:SKG6/TOS2-like | 1 / 66 | 7 / 15133 | 32.755 | 1.000 |
| IPR005282 | Family:Lysosomal cystine transporter | 1 / 66 | 8 / 15133 | 28.661 | 1.000 |
| IPR038843 | Family:Cell wall protein Sed1/Spi1 | 1 / 66 | 8 / 15133 | 28.661 | 1.000 |
Top 15 GO terms (whole set, family level) — secondary, computational evidence (IEA/IBA) included
15 rows shown, ordered by FDR then p-value; 15 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) | GO evidence | Families with non-IEA |
|---|---|---|---|---|---|---|---|
| GO:0030118 | cellular_component:clathrin coat | 6 / 43 | 18 / 13082 | 101.411 | 3.55e-08 | has_non_IEA | 1 |
| GO:0030125 | cellular_component:clathrin vesicle coat | 6 / 43 | 18 / 13082 | 101.411 | 3.55e-08 | has_non_IEA | 1 |
| GO:0030276 | molecular_function:clathrin binding | 6 / 43 | 37 / 13082 | 49.335 | 2.83e-06 | has_non_IEA | 1 |
| GO:0030120 | cellular_component:vesicle coat | 6 / 43 | 47 / 13082 | 38.838 | 9.57e-06 | has_non_IEA | 1 |
| GO:0005768 | cellular_component:endosome | 9 / 43 | 212 / 13082 | 12.916 | 2.04e-05 | has_non_IEA | 2 |
| GO:0030117 | cellular_component:membrane coat | 6 / 43 | 59 / 13082 | 30.939 | 2.60e-05 | has_non_IEA | 1 |
| GO:0031410 | cellular_component:cytoplasmic vesicle | 9 / 43 | 309 / 13082 | 8.861 | 2.95e-04 | has_non_IEA | 2 |
| GO:0097708 | cellular_component:intracellular vesicle | 9 / 43 | 309 / 13082 | 8.861 | 2.95e-04 | has_non_IEA | 2 |
| GO:0140940 | molecular_function:histone H2A methyltransferase activity | 3 / 43 | 6 / 13082 | 152.116 | 2.95e-04 | has_non_IEA | 2 |
| GO:1990259 | molecular_function:histone H2AQ104 methyltransferase activity | 3 / 43 | 6 / 13082 | 152.116 | 2.95e-04 | has_non_IEA | 2 |
| GO:0031982 | cellular_component:vesicle | 9 / 43 | 319 / 13082 | 8.583 | 3.02e-04 | has_non_IEA | 2 |
| GO:0036009 | molecular_function:protein-glutamine N-methyltransferase activity | 3 / 43 | 9 / 13082 | 101.411 | 0.001 | has_non_IEA | 2 |
| GO:0000494 | biological_process:box C/D sno(s)RNA 3'-end processing | 3 / 43 | 10 / 13082 | 91.27 | 0.001 | has_non_IEA | 2 |
| GO:0031428 | cellular_component:box C/D methylation guide snoRNP complex | 3 / 43 | 11 / 13082 | 82.973 | 0.002 | has_non_IEA | 2 |
| GO:0170049 | cellular_component:box C/D RNP complex | 3 / 43 | 13 / 13082 | 70.208 | 0.003 | has_non_IEA | 2 |
Actin cytoskeleton controls
Known actin-related families and how many of their proteins pass each filter. Protein ID columns are left out.
| control | pfam_ids | desc_regex | OUT_universe | OUT_in_matrix | OUT_pass_outgroup_rule | candidates | near_miss_in1 | near_miss_in2 | n_Komaphaf | n_Ogatpara | n_Kuracaps | n_Pichmemb | n_Pichkudr | n_Bretnaar | n_Eeninana | n_Ogatpoly | n_Pachtann | n_Sacccere | n_Kluylact | n_Lachther | n_Candglab | n_Torudelb | n_Eremgoss | n_Candalbi | n_Canddubl | n_Candtrop | n_Loddelon | n_Meyeguil | n_Debahans | n_Schestip | n_Spatpass | n_Hyphburt | n_Suhotanz | n_Candtenu | n_Babjinos | n_Diutrugo | n_Yamajaro | n_Candauri | n_Clavlusi | n_Metsbicu | n_Lizaspar |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arp2/3 ARPC2 (P34-Arc) | PF04045 | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC3 (P21-Arc) | PF04062 | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | |
| Arp2/3 ARPC4 | PF05856 | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC5 (P16-Arc) | PF04699 | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC1 (description only) | arp2/3 complex.*(41|p41|subunit 1)|ARPC1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Arp2 / Arp3 (description only) | actin-related protein (2|3)\b|\bARP[23]\b | 100 | 100 | 100 | 0 | 0 | 0 | 8 | 7 | 7 | 7 | 5 | 6 | 7 | 7 | 7 | 7 | 6 | 6 | 7 | 7 | 6 | 7 | 7 | 7 | 7 | 7 | 6 | 6 | 7 | 5 | 5 | 5 | 7 | 7 | 7 | 6 | 6 | 4 | 7 | |
| WAVE complex NCKAP1 | PF09735 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WAVE complex CYFIP (FragX_IP) | PF05994 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WAVE complex ABI | PF07815|PF27594 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| SCAR/WAVE (SCAR_helical) | PF27569 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WASP family (WH1) | PF00568 | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| WH2 motif (WASP, WAVE, others) | PF02205 | 24 | 24 | 24 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 0 | 2 | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | |
| Formin FH2 | PF02181 | 31 | 31 | 31 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | |
| Formin Drf_GBD / Drf_FH3 / Drf_DAD | PF06371|PF06367|PF06345 | 25 | 25 | 25 | 0 | 0 | 0 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | |
| Ena/VASP (VASP_tetra) | PF08776 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Coronin (description only) | coronin | 15 | 15 | 15 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | |
| Cortactin (HS1_rep) | PF02218 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Myosin 2 tail (Myosin_tail_1) | PF01576 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Myosin head (all myosins) | PF00063 | 49 | 49 | 49 | 0 | 0 | 0 | 3 | 3 | 3 | 2 | 4 | 3 | 3 | 3 | 3 | 5 | 3 | 3 | 5 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 1 | 2 | 0 | 3 | 3 | 3 | 3 | 3 | 2 | 3 |
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