serinales vs pichiales: functional enrichment (novelty)
One-sided hypergeometric test per term; Benjamini-Hochberg FDR within each scope, level and vocabulary. Candidates are the novelty candidates: gene families present in the IN group and absent from the OUT group. Universe: proteome. Background clustered: True (102522 sequences in 23051 clusters, mmseqs easy-cluster --min-seq-id 0.3 -c 0.8). Family level: one unit per candidate family and per background cluster.
Sources: Pfam: 2026-01-27-Pfam38.2; InterPro entries: 110.0; GO: releases/2026-07-26; analysis generated 2026-10-12T15:21:05. Source tables: studies/fungi/serinales_vs_pichiales/analysis/enrichment/outputs/proteome_clustered.
Full record: PROVENANCE. Run report: report.html.
Caveats
- Annotation provenance is not fully recorded: PROVENANCE.yaml lists the per-species annotation files and their checksums, but not the UniProt release they come from.
- GO results are secondary. GO annotations include computational evidence (IEA, IBA); the GO evidence column shows if a term has non-IEA support.
- Candidate families (pipeline clustering of candidates) and background clusters (mmseqs clustering of the background proteome) are made by different runs, so family-level counts are not fully comparable.
- Low annotation: the candidate set has less than 50% annotation for Pfam 40.8%, InterPro 47.4%, GO 28.5%, any vocabulary 48.5%. Enrichment for these vocabularies has low power.
Summary figure
Annotation coverage
Fraction of proteins with at least one term per vocabulary. Universe = all proteins of the species; candidates = the candidate set.
| Species | Set | Proteins | Pfam | Pfam clan | InterPro | GO | Any |
|---|---|---|---|---|---|---|---|
| Candalbi | universe | 6040 | 84.2% | 65.5% | 88.1% | 82.9% | 90.2% |
| Candalbi | candidates | 205 | 46.8% | 20.5% | 54.6% | 45.4% | 63.9% |
| Canddubl | universe | 5829 | 85.5% | 66.9% | 89.1% | 80.5% | 89.6% |
| Canddubl | candidates | 190 | 43.2% | 18.4% | 48.9% | 31.6% | 49.5% |
| Candtrop | universe | 6226 | 81.9% | 64.7% | 85.9% | 76.9% | 86.3% |
| Candtrop | candidates | 184 | 44.6% | 22.3% | 51.1% | 32.1% | 51.1% |
| Loddelon | universe | 5779 | 82.1% | 64.8% | 86.1% | 77.5% | 86.6% |
| Loddelon | candidates | 190 | 38.4% | 20.5% | 47.4% | 25.8% | 47.9% |
| Meyeguil | universe | 5919 | 85.5% | 68.6% | 89.1% | 80.3% | 89.4% |
| Meyeguil | candidates | 167 | 35.3% | 17.4% | 41.3% | 21.6% | 41.3% |
| Debahans | universe | 6284 | 83.2% | 65.2% | 86.6% | 78.1% | 86.8% |
| Debahans | candidates | 178 | 36.5% | 16.3% | 44.4% | 25.8% | 44.4% |
| Schestip | universe | 5797 | 87.4% | 69.0% | 90.8% | 82.2% | 91.1% |
| Schestip | candidates | 181 | 37.6% | 18.2% | 43.1% | 26.0% | 43.6% |
| Spatpass | universe | 5973 | 83.9% | 66.2% | 87.4% | 78.4% | 87.7% |
| Spatpass | candidates | 184 | 40.2% | 22.3% | 48.9% | 29.9% | 48.9% |
| Hyphburt | universe | 5993 | 82.8% | 65.2% | 86.2% | 77.8% | 86.5% |
| Hyphburt | candidates | 184 | 35.9% | 18.5% | 40.8% | 25.0% | 41.9% |
| Suhotanz | universe | 5881 | 81.5% | 63.8% | 84.5% | 76.5% | 84.7% |
| Suhotanz | candidates | 183 | 42.1% | 22.9% | 45.4% | 29.0% | 45.4% |
| Candtenu | universe | 5540 | 85.3% | 67.7% | 88.4% | 80.0% | 88.7% |
| Candtenu | candidates | 143 | 31.5% | 15.4% | 39.2% | 20.3% | 40.6% |
| Babjinos | universe | 6393 | 79.0% | 62.0% | 82.1% | 74.0% | 82.4% |
| Babjinos | candidates | 23 | 73.9% | 60.9% | 78.3% | 56.5% | 78.3% |
| Diutrugo | universe | 5811 | 81.2% | 64.5% | 84.9% | 75.5% | 85.2% |
| Diutrugo | candidates | 169 | 48.5% | 25.4% | 52.1% | 28.4% | 52.1% |
| Yamajaro | universe | 5820 | 86.8% | 68.5% | 90.2% | 81.0% | 90.5% |
| Yamajaro | candidates | 165 | 41.2% | 20.6% | 47.9% | 26.7% | 47.9% |
| Candauri | universe | 5433 | 86.7% | 68.6% | 89.7% | 79.6% | 90.0% |
| Candauri | candidates | 172 | 41.3% | 20.3% | 48.8% | 30.2% | 50.0% |
| Clavlusi | universe | 5932 | 79.7% | 63.0% | 83.0% | 74.8% | 83.3% |
| Clavlusi | candidates | 169 | 38.5% | 18.9% | 47.3% | 26.6% | 47.9% |
| Metsbicu | universe | 5826 | 79.2% | 61.3% | 82.6% | 74.5% | 82.9% |
| Metsbicu | candidates | 165 | 46.7% | 19.4% | 53.3% | 26.7% | 53.3% |
| Lizaspar | universe | 5041 | 86.9% | 68.5% | 90.8% | 81.8% | 91.1% |
| Lizaspar | candidates | 143 | 38.5% | 17.5% | 45.5% | 25.2% | 46.9% |
| ALL_IN | universe | 105517 | 83.4% | 65.7% | 86.9% | 78.4% | 87.3% |
| ALL_IN | candidates | 2995 | 40.8% | 20.1% | 47.4% | 28.5% | 48.5% |
Tests summary
Per vocabulary: terms with FDR < 0.05 / terms tested. Protein level counts proteins; family level counts candidate families and background clusters.
| Scope | Level | Cand. units | Pfam sig / tested | Pfam clan sig / tested | InterPro sig / tested | GO sig / tested |
|---|---|---|---|---|---|---|
| whole_set | family | 1234 | 31 / 1073 | 6 / 323 | 43 / 2161 | 11 / 4056 |
| whole_set | protein | 2995 | 86 / 4137 | 18 / 469 | 138 / 8628 | 167 / 6947 |
| Babjinos | family | 23 | 0 / 168 | 0 / 184 | 0 / 485 | 0 / 2453 |
| Babjinos | protein | 23 | 0 / 246 | 0 / 204 | 0 / 648 | 0 / 2598 |
| Candalbi | family | 184 | 1 / 173 | 0 / 185 | 1 / 500 | 0 / 2842 |
| Candalbi | protein | 205 | 4 / 249 | 1 / 204 | 5 / 672 | 12 / 2967 |
| Candauri | family | 163 | 1 / 159 | 0 / 180 | 1 / 462 | 0 / 2008 |
| Candauri | protein | 172 | 2 / 207 | 1 / 194 | 3 / 576 | 6 / 2114 |
| Canddubl | family | 177 | 1 / 172 | 0 / 181 | 1 / 491 | 0 / 1990 |
| Canddubl | protein | 190 | 2 / 247 | 1 / 200 | 3 / 658 | 8 / 2144 |
| Candtenu | family | 140 | 0 / 146 | 0 / 172 | 0 / 440 | 0 / 1878 |
| Candtenu | protein | 143 | 1 / 205 | 0 / 191 | 1 / 591 | 0 / 2031 |
| Candtrop | family | 178 | 1 / 184 | 0 / 183 | 1 / 511 | 0 / 2475 |
| Candtrop | protein | 184 | 2 / 255 | 1 / 194 | 3 / 666 | 1 / 2611 |
| Clavlusi | family | 169 | 1 / 170 | 0 / 187 | 1 / 494 | 0 / 2430 |
| Clavlusi | protein | 169 | 1 / 210 | 0 / 199 | 1 / 590 | 0 / 2499 |
| Debahans | family | 174 | 1 / 176 | 0 / 182 | 1 / 496 | 0 / 2526 |
| Debahans | protein | 178 | 1 / 240 | 0 / 204 | 2 / 646 | 0 / 2649 |
| Diutrugo | family | 164 | 1 / 159 | 0 / 183 | 1 / 462 | 0 / 1891 |
| Diutrugo | protein | 169 | 2 / 224 | 1 / 205 | 3 / 595 | 3 / 2035 |
| Hyphburt | family | 179 | 0 / 167 | 0 / 182 | 0 / 491 | 0 / 2472 |
| Hyphburt | protein | 184 | 0 / 218 | 1 / 197 | 0 / 621 | 4 / 2574 |
| Lizaspar | family | 142 | 0 / 151 | 0 / 172 | 0 / 461 | 0 / 1862 |
| Lizaspar | protein | 143 | 0 / 197 | 0 / 187 | 0 / 556 | 0 / 1969 |
| Loddelon | family | 186 | 1 / 170 | 0 / 181 | 1 / 479 | 0 / 2387 |
| Loddelon | protein | 190 | 1 / 225 | 0 / 200 | 1 / 601 | 1 / 2496 |
| Metsbicu | family | 165 | 0 / 143 | 0 / 175 | 0 / 430 | 0 / 2411 |
| Metsbicu | protein | 165 | 0 / 195 | 0 / 186 | 0 / 550 | 0 / 2507 |
| Meyeguil | family | 166 | 0 / 174 | 0 / 176 | 0 / 505 | 0 / 2478 |
| Meyeguil | protein | 167 | 0 / 226 | 0 / 190 | 0 / 628 | 0 / 2576 |
| Schestip | family | 176 | 0 / 165 | 0 / 183 | 0 / 482 | 0 / 2499 |
| Schestip | protein | 181 | 1 / 239 | 0 / 203 | 1 / 647 | 3 / 2640 |
| Spatpass | family | 177 | 1 / 175 | 1 / 182 | 1 / 502 | 0 / 2479 |
| Spatpass | protein | 184 | 2 / 224 | 2 / 196 | 2 / 617 | 7 / 2582 |
| Suhotanz | family | 177 | 1 / 163 | 0 / 181 | 5 / 469 | 0 / 2441 |
| Suhotanz | protein | 183 | 1 / 217 | 1 / 192 | 1 / 579 | 4 / 2550 |
| Yamajaro | family | 162 | 1 / 167 | 0 / 174 | 1 / 474 | 0 / 1918 |
| Yamajaro | protein | 165 | 1 / 235 | 1 / 194 | 1 / 635 | 1 / 2050 |
Top 25 Pfam terms (whole set, family level)
25 rows shown, ordered by FDR then p-value; 25 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) |
|---|---|---|---|---|---|
| PF29124 | MSC3_beta: Meiotic sister-chromatid recombination protein 3 beta-sheet domain | 10 / 477 | 11 / 13407 | 25.552 | 3.39e-11 |
| PF05730 | CFEM: CFEM domain | 13 / 477 | 24 / 13407 | 15.225 | 1.17e-10 |
| PF29143 | PGA45_C: GPI-anchored protein 45 C-terminal domain | 9 / 477 | 10 / 13407 | 25.296 | 2.94e-10 |
| PF29045 | YOL036W_C: YOL036W-like C-terminal domain | 7 / 477 | 7 / 13407 | 28.107 | 1.85e-08 |
| PF03583 | LIP: Secretory lipase | 6 / 477 | 6 / 13407 | 28.107 | 3.52e-07 |
| PF11214 | Med2: Mediator complex subunit 2 | 6 / 477 | 6 / 13407 | 28.107 | 3.52e-07 |
| PF27837 | Fyv8: Protein Fyv8 | 6 / 477 | 8 / 13407 | 21.08 | 6.66e-06 |
| PF12632 | Vezatin: Mysoin-binding motif of peroxisomes | 5 / 477 | 5 / 13407 | 28.107 | 6.66e-06 |
| PF28466 | DUF8407: Domain of unknown function (DUF8407) | 5 / 477 | 5 / 13407 | 28.107 | 6.66e-06 |
| PF12657 | TFIIIC_delta: Transcription factor IIIC subunit delta bet-propeller domain | 6 / 477 | 9 / 13407 | 18.738 | 1.24e-05 |
| PF18497 | RNase_3_N: Ribonuclease III N-terminal domain | 6 / 477 | 9 / 13407 | 18.738 | 1.24e-05 |
| PF29116 | PET130: Mitochondrial protein PET130 | 6 / 477 | 9 / 13407 | 18.738 | 1.24e-05 |
| PF29481 | SKG1: SKG1 domain | 6 / 477 | 9 / 13407 | 18.738 | 1.24e-05 |
| PF29044 | FGR15_N: Filamentous growth regulator 15 N-terminal domain | 7 / 477 | 14 / 13407 | 14.053 | 1.46e-05 |
| PF04478 | Mid2: Mid2 like cell wall stress sensor | 5 / 477 | 7 / 13407 | 20.076 | 7.91e-05 |
| PF02257 | RFX_DNA_binding: RFX DNA-binding domain | 6 / 477 | 13 / 13407 | 12.972 | 1.83e-04 |
| PF00498 | FHA: FHA domain | 9 / 477 | 37 / 13407 | 6.837 | 2.73e-04 |
| PF15511 | CENP-T_C: Centromere kinetochore component CENP-T histone fold | 5 / 477 | 9 / 13407 | 15.615 | 3.73e-04 |
| PF13094 | CENP-Q: CENP-Q, a CENPA-CAD centromere complex subunit | 5 / 477 | 10 / 13407 | 14.053 | 6.85e-04 |
| PF03134 | TB2_DP1_HVA22: TB2/DP1, HVA22 family | 5 / 477 | 11 / 13407 | 12.776 | 0.001 |
| PF07954 | DUF1689: Protein of unknown function (DUF1689) | 5 / 477 | 11 / 13407 | 12.776 | 0.001 |
| PF20789 | 4HBT_3C: Acyl-CoA thioesterase C-terminal domain | 4 / 477 | 6 / 13407 | 18.738 | 0.001 |
| PF29317 | AIM44: Altered inheritance of mitochondria protein 44 | 4 / 477 | 6 / 13407 | 18.738 | 0.001 |
| PF01399 | PCI: PCI domain | 7 / 477 | 26 / 13407 | 7.567 | 0.001 |
| PF11488 | Lge1: Transcriptional regulatory protein LGE1 | 4 / 477 | 7 / 13407 | 16.061 | 0.002 |
Top 25 InterPro terms (whole set, family level)
25 rows shown, ordered by FDR then p-value; 25 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) |
|---|---|---|---|---|---|
| IPR062021 | Domain:Meiotic sister-chromatid recombination protein 3, beta-sheet domain | 10 / 571 | 11 / 14550 | 23.165 | 1.84e-10 |
| IPR008427 | Domain:Extracellular membrane protein, CFEM domain | 13 / 571 | 24 / 14550 | 13.803 | 8.30e-10 |
| IPR063250 | Domain:GPI-anchored protein 45, C-terminal | 9 / 571 | 10 / 14550 | 22.933 | 1.44e-09 |
| IPR051735 | 9 / 571 | 11 / 14550 | 20.849 | 5.75e-09 | |
| IPR062062 | Domain:YOL036W-like, C-terminal domain | 7 / 571 | 7 / 14550 | 25.482 | 5.98e-08 |
| IPR005152 | Family:Lipase, secreted | 7 / 571 | 8 / 14550 | 22.296 | 3.85e-07 |
| IPR021017 | Family:Mediator complex, subunit Med2, fungi | 6 / 571 | 6 / 14550 | 25.482 | 1.10e-06 |
| IPR026859 | Domain:Myosin-binding domain | 5 / 571 | 5 / 14550 | 25.482 | 2.01e-05 |
| IPR059451 | Domain:Domain of unknown function DUF8407 | 5 / 571 | 5 / 14550 | 25.482 | 2.01e-05 |
| IPR026248 | Family:Protein Fyv8 | 6 / 571 | 8 / 14550 | 19.111 | 2.01e-05 |
| IPR000999 | Domain:Ribonuclease III domain | 8 / 571 | 18 / 14550 | 11.325 | 3.25e-05 |
| IPR024761 | Domain:Transcription factor IIIC, 90kDa subunit, N-terminal | 6 / 571 | 9 / 14550 | 16.988 | 3.89e-05 |
| IPR040540 | Domain:Ribonuclease III, N-terminal domain | 6 / 571 | 9 / 14550 | 16.988 | 3.89e-05 |
| IPR062383 | Family:Mitochondrial protein PET130 | 6 / 571 | 9 / 14550 | 16.988 | 3.89e-05 |
| IPR063222 | Domain:SKG1-like domain | 6 / 571 | 9 / 14550 | 16.988 | 3.89e-05 |
| IPR062451 | Domain:Filamentous growth regulator 15. N-terminal domain | 7 / 571 | 14 / 14550 | 12.741 | 5.04e-05 |
| IPR036389 | Homologous_superfamily:Ribonuclease III, endonuclease domain superfamily | 8 / 571 | 22 / 14550 | 9.266 | 1.34e-04 |
| IPR007567 | Domain:Mid2 domain | 5 / 571 | 7 / 14550 | 18.201 | 2.16e-04 |
| IPR011032 | Homologous_superfamily:GroES-like superfamily | 9 / 571 | 37 / 14550 | 6.198 | 0.001 |
| IPR035425 | Domain:CENP-T/Histone H4, histone fold | 5 / 571 | 9 / 14550 | 14.156 | 0.001 |
| IPR003703 | Family:Acyl-CoA thioesterase | 5 / 571 | 10 / 14550 | 12.741 | 0.002 |
| IPR025212 | Family:Centromere protein Q | 5 / 571 | 10 / 14550 | 12.741 | 0.002 |
| IPR003150 | Domain:DNA-binding RFX-type, winged-helix domain | 6 / 571 | 16 / 14550 | 9.556 | 0.002 |
| IPR008984 | Homologous_superfamily:SMAD/FHA domain superfamily | 9 / 571 | 42 / 14550 | 5.46 | 0.003 |
| IPR049450 | Domain:Acyl-CoA thioesterase-like, C-terminal domain | 4 / 571 | 6 / 14550 | 16.988 | 0.003 |
Top 15 GO terms (whole set, family level) — secondary, computational evidence (IEA/IBA) included
15 rows shown, ordered by FDR then p-value; 11 have FDR < 0.05 (bold).
| Term | Name | k / N cand. | n / M bg | Fold | FDR (BH) | GO evidence | Families with non-IEA |
|---|---|---|---|---|---|---|---|
| GO:0016042 | biological_process:lipid catabolic process | 14 / 332 | 82 / 12151 | 6.249 | 1.32e-04 | has_non_IEA | 4 |
| GO:0004525 | molecular_function:ribonuclease III activity | 8 / 332 | 23 / 12151 | 12.73 | 1.32e-04 | has_non_IEA | 1 |
| GO:0032296 | molecular_function:double-stranded RNA-specific ribonuclease activity | 8 / 332 | 23 / 12151 | 12.73 | 1.32e-04 | has_non_IEA | 1 |
| GO:0017022 | molecular_function:myosin binding | 5 / 332 | 9 / 12151 | 20.333 | 0.002 | IEA_only | 0 |
| GO:0005782 | cellular_component:peroxisomal matrix | 7 / 332 | 25 / 12151 | 10.248 | 0.002 | has_non_IEA | 2 |
| GO:0031907 | cellular_component:microbody lumen | 7 / 332 | 25 / 12151 | 10.248 | 0.002 | has_non_IEA | 2 |
| GO:0008541 | cellular_component:proteasome regulatory particle, lid subcomplex | 7 / 332 | 29 / 12151 | 8.834 | 0.005 | IEA_only | 0 |
| GO:0047617 | molecular_function:fatty acyl-CoA hydrolase activity | 5 / 332 | 12 / 12151 | 15.25 | 0.005 | IEA_only | 0 |
| GO:0016289 | molecular_function:acyl-CoA hydrolase activity | 5 / 332 | 13 / 12151 | 14.077 | 0.007 | IEA_only | 0 |
| GO:0004806 | molecular_function:triacylglycerol lipase activity | 7 / 332 | 32 / 12151 | 8.006 | 0.008 | has_non_IEA | 1 |
| GO:0005576 | cellular_component:extracellular region | 16 / 332 | 189 / 12151 | 3.098 | 0.023 | has_non_IEA | 7 |
| GO:0008534 | molecular_function:oxidized purine nucleobase lesion DNA N-glycosylase activity | 3 / 332 | 5 / 12151 | 21.96 | 0.066 | has_non_IEA | 1 |
| GO:0000372 | biological_process:Group I intron splicing | 4 / 332 | 12 / 12151 | 12.2 | 0.066 | IEA_only | 0 |
| GO:0000376 | biological_process:RNA splicing, via transesterification reactions with guanosine as nucleophile | 4 / 332 | 12 / 12151 | 12.2 | 0.066 | IEA_only | 0 |
| GO:0016790 | molecular_function:thiolester hydrolase activity | 5 / 332 | 22 / 12151 | 8.318 | 0.072 | IEA_only | 0 |
Actin cytoskeleton controls
Known actin-related families and how many of their proteins pass each filter. Protein ID columns are left out.
| control | pfam_ids | desc_regex | IN_universe | IN_in_matrix | IN_pass_ingroup_rule | candidates | near_miss_out1 | near_miss_out2 | n_Candalbi | n_Canddubl | n_Candtrop | n_Loddelon | n_Meyeguil | n_Debahans | n_Schestip | n_Spatpass | n_Hyphburt | n_Suhotanz | n_Candtenu | n_Babjinos | n_Diutrugo | n_Yamajaro | n_Candauri | n_Clavlusi | n_Metsbicu | n_Lizaspar | n_Komaphaf | n_Ogatpara | n_Kuracaps | n_Pichmemb | n_Pichkudr | n_Bretnaar | n_Eeninana | n_Ogatpoly | n_Pachtann | n_Sacccere | n_Kluylact | n_Lachther | n_Candglab | n_Torudelb | n_Eremgoss |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arp2/3 ARPC2 (P34-Arc) | PF04045 | 18 | 18 | 18 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC3 (P21-Arc) | PF04062 | 17 | 17 | 17 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC4 | PF05856 | 18 | 18 | 18 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC5 (P16-Arc) | PF04699 | 18 | 18 | 18 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Arp2/3 ARPC1 (description only) | arp2/3 complex.*(41|p41|subunit 1)|ARPC1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Arp2 / Arp3 (description only) | actin-related protein (2|3)\b|\bARP[23]\b | 113 | 113 | 113 | 0 | 0 | 0 | 7 | 7 | 7 | 7 | 7 | 6 | 6 | 7 | 5 | 5 | 5 | 7 | 7 | 7 | 6 | 6 | 4 | 7 | 8 | 7 | 7 | 7 | 5 | 6 | 7 | 7 | 7 | 7 | 6 | 6 | 7 | 7 | 6 | |
| WAVE complex NCKAP1 | PF09735 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WAVE complex CYFIP (FragX_IP) | PF05994 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WAVE complex ABI | PF07815|PF27594 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| SCAR/WAVE (SCAR_helical) | PF27569 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| WASP family (WH1) | PF00568 | 17 | 17 | 17 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| WH2 motif (WASP, WAVE, others) | PF02205 | 30 | 30 | 30 | 0 | 0 | 0 | 2 | 3 | 3 | 3 | 0 | 2 | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 0 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | |
| Formin FH2 | PF02181 | 35 | 35 | 35 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | |
| Formin Drf_GBD / Drf_FH3 / Drf_DAD | PF06371|PF06367|PF06345 | 31 | 31 | 31 | 0 | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | |
| Ena/VASP (VASP_tetra) | PF08776 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Coronin (description only) | coronin | 13 | 13 | 13 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Cortactin (HS1_rep) | PF02218 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Myosin 2 tail (Myosin_tail_1) | PF01576 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Myosin head (all myosins) | PF00063 | 47 | 47 | 47 | 0 | 0 | 0 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 1 | 2 | 0 | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | 2 | 4 | 3 | 3 | 3 | 3 | 5 | 3 | 3 | 5 | 3 | 3 |
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